个人简介

中山大学免疫学博士。深圳中山妇产医院检验中心主任。
擅长领域：慢性子宫内膜炎诊断标准与致病机制、子宫内膜免疫微环境预测指标及临床干预策略。
社会任职：中国免疫学会生殖免疫分会第五届委员会委员、妇幼健康研究会生殖免疫学专业委员会委员、美国生殖免疫协会会员。　

学术成果：　

主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序)：
1、 深圳市自然科学基金、JCYJ20190803142103857、早孕期滋养细胞通过IDO-AhR诱导蜕膜CD8+T细胞PD-1表达的机制研究、2020/08-2023/08，10万，在研，主持。
2、 国家自然科学基金青年项目、81601279、子宫内膜CD8+T细胞通过Fas通路促进滋养细胞侵袭的分子机制研究，2017/01-2019/12，17.5万，主持，结题。
3、中华医学会临床医学科研专项资金、16020200636、子宫内膜CD8+T细胞对滋养层细胞调控机制的研究，2017/01-201912，11万，主持，结题。
代表性研究成果和学术奖励
一、期刊论文 1. 第一作者或通讯作者论文
(1)Li Yuye # ，Xu Shiru# , Yu Shuyi, Huang Chunyu, Lin Shenglai, Chen Wanru, Mo Meilan, Lian Ruochun, Diao Lianghui, Ding Lijun *, Zeng Yong *, Diagnosis of chronic endometritis: 2 How many CD138 + cells/HPF in endometrial stroma affect pregnancy outcome of infertile women? doi:10.1111 /aji.13369.(第一作者)
(2) Diao, Lianghui(#), Songchen Cai(#), Chunyu Huang, Longfei Li, Shuyi Yu, Linlin Wang, Su Liu, Yuye Li(*), and Yong Zeng(*). New Endometrial Immune Cell-Based Score (Ei-Score) for the Prediction of Implantation Success for Patients Undergoing IVF/ICSI, Placenta (2020) 99, 180-188. (通讯作者)
(3) Li Yuye(#), Yu Shuyi(#), Huang Chunyu, Lian Rruochun, Chen Cong, Liu Su, Li Longfei, Diao Lianghui, Udo R Markert(*), Zeng Yong(*). Evaluation of peripheral and uterine immune status of chronic endometritis in patients with recurrent reproductive failure. Fertil Steril 2019. (第一作者)
(4) Yin Biao(#), Zeng Yong, Wu Tonghua, Yu Shuyi, Xu Jian, Liu Su, Diao Lianghui, Zhao Zhengfu, Desheng Liang(*), Li Yuye(*). Functional properties of peripheral CD8(+) T cells in patients with repeated implantation failure. Am J Reprod Immunol 2017;78.(通讯作者)
(5) Li Yuye(#), Wu Siyu, Pu Jieying, et al. Dengue Virus Upregulates Expression of Notch Ligands Dll1 and Dll4 Through IFN- β Signaling Pathway. Immunology, 2015 Jan;144(1):127-38. (第一作者)
(6) Zhang Peifen(#), Li Yuye(#), Xia Jiong, He Junfang, Pu Jieying, Xie Jiong et al. IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its activation. J Cell Sci 2014;127:2471-82.(第一作者)
(7) Li Yuye(#), Xie Jiong, Wu Siyu, et al. Protein kinase regulated by dsRNA downregulates the interferon production in dengue virus- and dsRNA-stimulated human lung epithelial cells. PLoS One 2013;8:e55108.(第一作者)
2. 既非第一作者又非通讯作者论文
(1) Liu S, Wei H, Li Y, Diao L, Lian R, Zhang X et al. Characterization of Dendritic Cell(DC)10 in recurrent miscarriage and recurrent implantation failure. Reproduction 2019.
(2) Wei H, Liu S, Lian R, Huang C, Li Y, Chen L et al. Abnormal Expression of Indoleamine 2, 3-Dioxygenase in Human Recurrent Miscarriage. Reprod Sci 2019:1933719119833788.
(3) Wang L, Li L, Huang C, Diao L, Lian R, Li Y et al. Maternal chronic hepatitis B virus infection does not affect pregnancy outcomes in infertile patients receiving first in vitro 3 fertilization treatment. Fertil Steril 2019;112:250-7 e1.
(4) Liu S, Wei H, Li Y, Huang C, Lian R, Xu J et al. Downregulation of ILT4(+) dendritic cells in recurrent miscarriage and recurrent implantation failure. Am J Reprod Immunol 2018;80:e12998.
(5) Liu S, Diao L, Huang C, Li Y, Zeng Y, Kwak-Kim JYH. The role of decidual immune cells on human pregnancy. J Reprod Immunol 2017;124:44-53.
(6) Pu J, Wu S, Xie H, Li Y, Yang Z, Wu X et al. miR-146a Inhibits dengue-virus-induced autophagy by targeting TRAF6. Arch Virol 2017;162:3645-59.
(7) Pu J, He L, Xie H, Wu S, Li Y, Zhang P et al. Antiviral activity of Carbenoxolone disodium against dengue virus infection. J Med Virol 2017;89:571-81.
(8) Xia J, Chen X, Xu F, Wang Y, Shi Y, Li Y et al. Dengue virus infection induces formation of G3BP1 granules in human lung epithelial cells. Arch Virol 2015;160:2991-9.
(9) Wu S, He L, Li Y, Wang T, Feng L, Jiang L et al. miR-146a facilitates replication of dengue virus by dampening interferon induction by targetingTRAF6. J Infect 2013;67:329-41.