姓名:刁梁辉

职称/头衔:副院长/生殖医学临床研究中心主任

所属科室:生殖医学临床研究中心/生殖免疫中心

从业年限:

技术专业:子宫内膜接受性的生物标记物筛选,子宫内膜微环境的免疫学调控机制及反复胚胎着床失败的临床干预策略


个人简介

        博士、高级工程师、副研究员,深圳中山妇产医院生殖医学临床研究中心主任。研究方向:生殖免疫代谢,子宫内膜微环境调控机制及干预策略。以项目负责人主持(含在研及结题)国家、省、市级科研项目7项,以第一作者或通讯作者(含共同)发表SCI论文16篇,截至2023年8月,谷歌学术统计论文引用1252次。获批国家发明及实用新型专利3项。获深圳市科技进步一等奖(2022年)及湖北省科技进步二等奖(2023年)。学术任职:《Journal of Reproductive Immunology》Editor Board Member(2022年起),《American Journal of Reproductive Immunology》Guest Editor(2021年起),《中华生殖与避孕杂志》通讯编委(2020年起),广东省免疫学会生殖免疫专业委员会副主任委员(2021年起),深圳市母胎医学专委会青年委员会副主任委员(2023年起)。

  工作经历

  2019/07 - 至 今,深圳中山妇产医院,生殖医学临床研究中心,主任

  2019/07 - 至 2023/05,深圳中山妇产医院,科教科,主任

  2017/05 - 2019/05,德国汉堡大学附属艾本德医学中心母胎医学实验室,博士后

  2012/08 – 2017/03,深圳中山妇产医院,生殖医学中心,助理研究员

  教育经历

  2007/09 - 2012/07,中山大学,生物化学与分子生物学,博士,导师:李迎秋

  2003/09 - 2007/07,中山大学,生物化学与分子生物学,本科,导师:李迎秋

  主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序):

  1、国家自然科学基金-面上项目、82371684、CD36棕榈酰化介导脂肪酸代谢调控蜕膜巨噬细胞功能的机制研究 2024/1-2027/12,45万,在研,主持

  2、广东省自然科学基金-面上项目、2023A1515011675 子宫FOLR2+巨噬细胞调控胚胎种植的分子机制研究 2023/1-2025/12,10万,在研,主持

  3、广东省自然科学基金-面上项目、2022A1515010650 糖皮质激素受体介导的信号调控树突状细胞谷氨酰胺代谢促进妊娠的机制研究 2022/1-2024/12,10万,在研,主持

  4、深圳市自然科学基金、JCYJ20190813161801676、母胎界面DC细胞和T细胞代谢功能适应性调节的分子机制、2020/08-2023/08,20万,在研,主持。

  5、国家自然科学基金青年项目、81701529、HIF-1α与雌激素协同调控Tregs功能和子宫内膜微环境的机制研究、2018/01-2020/12,20万,结题、主持。

  6、广东省科技发展专项资金项目、2017A020214006、子宫驻留调节性T细胞参与调控免疫微环境和胚胎种植的机制研究、2017/01-2019/12,30万,结题,主持。

  7、深圳市科技创新委基础研究项目、JCYJ20140415114504394、Treg在种植窗期活化迁移的调控因素及其信号通路、2014/09-2016/09、20万,结题、主持。

  代表性研究成果和学术奖励(近五年)

  一、期刊论文

  1. 第一作者或通讯作者论文(含共同)

  (1) Fangfang Jin, Wei Liu, Guan Cheng, Songchen Cai, Tailang Yin*, Lianghui Diao*. The function of decidua natural killer cells in physiology and pathology of pregnancy. American Journal of Reproductive Immunology 90, no. 3 (2023): e13755.

  (2) Cai, Songchen, Su Dai, Rong Lin, Chunyu Huang, Yong Zeng, Lianghui Diao*, Ruochun Lian*, and Wenwei Tu*. "The effectiveness and safety of intrauterine infusion of autologous regulatory T cells (Tregs) in patients with recurrent pregnancy loss and low levels of endometrial FoxP3+ cells: A retrospective cohort study." American Journal of Reproductive Immunology 90, no. 2 (2023): e13735.

  (3) Li, Dajin, Meirong Du, Aihua Liao, Aimin Zhao, and Lianghui Diao*. "Editorial for the special issue on “Clinical reproductive immunology in China”." American Journal of Reproductive Immunology: e13705.

  (4) Yang, Dongyong, Fangfang Dai, Linlin Wang, Songchen Cai, Yuwei Zhang, Lianghui Diao*, and Yanxiang Cheng*. "HSP70 regulates lipid metabolism of decidual macrophages to maintain normal pregnancy." Journal of Reproductive Immunology 156 (2023): 103829.

  (5) Zeng, Yong, Bin Cao, Lianghui Diao*, and Joanne Kwak-Kim*. "New trends in clinical and basic research of maternal-fetal medicine in China." J Reprod Immunol (2023): 103810-103810.

  (6) Ma, Huan, Songchen Cai, Lingtao Yang, Linlin Wang, Jinli Ding, Longfei Li, Hanjie Li, Chunyu Huang*, and Lianghui Diao*. "How do pre-pregnancy endometrial macrophages contribute to pregnancy?." Journal of Reproductive Immunology (2022): 103736.

  (7) Songchen Cai(#), Rong Lin(#), Su Liu, Xiaohui Wang, Hongxia Wei, Chunyu Huang, Yuye Li, Xian Chen, Longfei Li, Yong Zeng, Ruochun Lian*, Lianghui Diao*. (2022). Intrauterine infusion of human chorionic gonadotropin improves the endometrial FoxP3+ Tregs level and pregnancy outcomes in patients with lower endometrial FoxP3+ Tregs. Journal of Reproductive Immunology, 103678.

  (8) Su Liu(#), Ling Hong(#), Ruochun Lian, Shan Xiao, Yuye Li, Lianghui Diao* and Yong Zeng*. (2022). Transcriptomic Analysis Reveals Endometrial Dynamics in Normoweight and Overweight/Obese Polycystic Ovary Syndrome Women. Frontiers in Genetics 2022.13;13:874487.

  (9) Diao, Lianghui(#), Alexandra Maximiliane Hierweger, Agnes Wieczorek, Petra Clara Arck, and Kristin Thiele*. 'Disruption of Glucocorticoid Action on CD11c+ Dendritic Cells Favors the Generation of CD4+ Regulatory T Cells and Improves Fetal Development in Mice', Frontiers in immunology, 2021.12. 729742

  (10) Peilin Chen(#), Chunyu Huang(#),Qing Sun, Huixian Zhong, Feng Xiong, Su Liu, Zhihong Yao, Zhiqiang Liu, Caiyun Wan, Yong Zeng*, Lianghui Diao* Granulocyte-Macrophage Colony Stimulating Factor in Single Blastocyst Conditioned Medium as a Biomarker for Predicting Implantation Outcome of Embryo. Frontiers in Immunology. 2021. 12, 2566.

  (11) Lijun Ye(#), Wensi Huang(#), Su Liu, Songchen Cai, Ling Hong, Weiqiang Xiao, Kristin Thiele, Yong Zeng, Mingzhe Song*, and Lianghui Diao*. Impacts of Immunometabolism on male reproduction. Frontiers in Immunology 2021. 12, 2828.

  (12) Xueling Zhang(#), Yuye Li, Chunyu Huang, Su Liu, Xian Chen, Shuyi Yu, Lianghui Diao*, and Yong Zeng*. The role of decidual natural killer cell derived soluble factors in early pregnancy. American Journal of Reproductive Immunology, 2021. e13477.

  (13) Ling Hong(#), Yuan chang Zhu, Su Liu, Tonghua Wu, Yuye Li, Lijun Ye, Lianghui Diao*, Yong Zeng*: Multi-omics reveals a relationship between endometrial amino acid metabolism and autophagy in women with recurrent miscarriage. Biol Reprod 2021.

  https://doi.org/10.1093/biolre/ioab101

  (14) Su Liu(#), Ling Hong, Meilan Mo, Shan Xiao, Cong Chen, Yuye Li, Ruochun Lian, Xuejin Wang, Songchen Cai, Lianghui Diao*, Yong Zeng*. Evaluation of endometrial immune status of polycystic ovary syndrome, Journal of Reproductive Immunology, (2021): 103282.

  (15) Su Liu(#), Meilan Mo, Shan Xiao, Longfei Li, Xiuyu Hu, Ling Hong, Linlin Wang, Ruochun Lian, Chunyu Huang, Yong Zeng* and Lianghui Diao*. Pregnancy outcomes of women with polycystic ovary syndrome for the first in vitro fertilization treatment: A retrospective cohort study with 7678 patients. Front. Endocrinol, (2021), 103282.

  (16) Diao, Lianghui(#), Songchen Cai(#), Chunyu Huang, Longfei Li, Shuyi Yu, Linlin Wang, Su Liu, Yuye Li(*), and Yong Zeng(*). New Endometrial Immune Cell-Based Score (Ei-Score) for the Prediction of Implantation Success for Patients Undergoing IVF/ICSI, Placenta (2020) 99, 180-188.

  2. 既非第一作者又非通讯作者论文

  (1) Yu, Shuyi, Lianghui Diao, Ruochun Lian, Cong Chen, Chunyu Huang, Xinyuan Li, Yuye Li, and Yong Zeng. "Comparing the peri-implantation endometrial T-bet/GATA3 ratio between control fertile women and patients with recurrent miscarriage: establishment and application of a reference range." Human Reproduction (2023): dead132.

  (2) Yu, Shuyi, Chunyu Huang, Ruochun Lian, Lianghui Diao, Xueling Zhang, Songchen Cai, Hongxia Wei, Cong Chen, Yuye Li, and Yong Zeng. "Establishment of reference intervals of endometrial immune cells during the mid-luteal phase." Journal of Reproductive Immunology 156 (2023): 103822.

  (3) Chen, Xian, Lianghui Diao, Ruochun Lian, Lingbin Qi, Shuyi Yu, Su Liu, Shenglai Lin, Zhigang Xue(*), and Yong Zeng(*). "Potential Impact of Maternal Vitamin D Status on Peripheral Blood and Endometrium Cellular Immunity in Women with Recurrent Implantation Failure." American Journal of Reproductive Immunology (2020): e13243.

  (4) Liu, Su(#), Hongxia Wei(#), Yuye Li, Lianghui Diao, Ruochun Lian, Xu Zhang, and Yong Zeng(*). "Characterization of Dendritic Cell (Dc) 10 in Recurrent Miscarriage and Recurrent Implantation Failure." Reproduction 1, no. aop (2019).

  (5) Wang, Linlin(#), Longfei Li(#), Chunyu Huang, Lianghui Diao, Ruochun Lian, Yuye Li, Shan Xiao, et al. "Maternal Chronic Hepatitis B Virus Infection Does Not Affect Pregnancy Outcomes in Infertile Patients Receiving First in Vitro Fertilization Treatment." Fertility and sterility 112, no. 2 (2019): 250-57. e1.

  (6) Thiele Kristin, Diao, Liang-Hui, Arck, Petra(*), Immunometabolism, pregnancy, and nutrition, Seminars in immunopathology, 2017, pp. 1-18.

  (7) Liu, Su, Diao, Liang-Hui, Huang, Chunyu , Li, Yuye, Zeng, Yong, Kwak-Kim, Joanne. The role of decidual immune cells on human pregnancy, Journal of reproductive immunology 124 (2017) 44-53.

  (8) Chen, Xian(#),Yin, Biao(#),Lian, Ruo-Chun,Zhang, Tao,Zhang, Hong-Zhan,Diao, Liang-Hui,Li, Yu-Ye,Huang, Chun-Yu ,Liang, De-Sheng(*),Zeng, Yong(*),Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage.,Am J Reprod Immunol,2016.12.01,76(6):432~438

  (9) Huang, Chunyu(#),Zhang, Hongzhan(#),Chen, Xian,Diao, Lianghui,Lian, Ruochun,Zhang, Xu,Hu, Lina(*),Zeng, Yong(*),Association of peripheral blood dendritic cells with recurrent pregnancy loss: a case-controlled study.,Am J Reprod Immunol,2016.10.01,76(4):326~332

  (10) Liang, Pei-Yan(#),Diao, Liang-Hui,Huang, Chun-Yu ,Lian, Ruo-Chun,Chen, Xian,Li, Guan-Gui,Zhao, Jin,Li, Yu-Ye,He, Xue-Bing,Zeng, Yong(*),The pro-inflammatory and anti-inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure.,Reprod Biomed Online,2015.12.01,31(6):823~826

  二、编著

  Yiqiu Wei(#), Songchen Cai(#), Jinli Ding, Yong Zeng, Tailang Yin*, Lianghui Diao*. (2022). Metabolic control of immune responses in women with recurrent pregnancy loss and recurrent implantation failure. Immunology of Recurrent Pregnancy Loss and Implantation Failure, 379-394

  Diao, Lianghui; Cai, Songchen; Ding, Jinli; Zeng, Yong; Metabolic and Nutritional Impact on Endometrial Gene Expression and Reproductive Disorder, Endometrial Gene Expression,2020, (199-214)

  三、特邀大会报告

  (1)Lianghui Diao; The Immunometabolism of early pregnancy - evidence from dendritic cells and regulatory T cells, 第一届(2019)母胎医学科学研究大会(厦门), 厦门大学, 2019-12-6至2019-12-9. (大会报告)

  (2)Lianghui Diao; Maria Emilia Solano; Yong Zeng; Kristin Thiele; Petra Arck; The immune metabolic adaptations during early pregnancy: lessons learned from tumor immunology, The 38th Annual Meeting of the American Society for Reproductive Immunology, 上海, 2018-6-28至2018-7-1. (大会报告)

  四、论著之外的代表性研究成果和专利

  (1)刁梁辉, 2023-06-09至2023-06-11, 举办第二届母胎医学科学研究大会暨第六届国际生殖免疫新进展学术研讨会,深圳.福田 会议规模:600人 (举办或参加学术会议)

  (2) 刁梁辉(2/13); 反复妊娠失败的诊疗策略和技术创新, 湖北省人民政府, 科技进步, 国家二等奖,2023 (程艳香; 刁梁辉; 赵晓苗; 曾勇; 李达; 黄春宇; 代芳芳; 王琳琳; 杨冬咏; 朱融慧; 邓志敏; 胡学佳; 熊风) (科研奖励)

  (3) 刁梁辉(3/8); 反复妊娠失败的围着床期诊疗策略和关键技术创新与推广, 深圳市人民政府, 科技进步, 省部一等奖, 2022(曾勇; 黄春宇; 刁梁辉; 熊风; 李玉叶; 陈现; 陈培林; 连若纯) (科研奖励)

  (4) 刁梁辉; 蔡松辰; 黄春宇; 李玉叶; 李龙飞; 余妹毅; 陈聪; 曾勇 ; 一种评估子宫内膜容受性的试剂盒, 2021-3-16, 中国, ZL 2020 2 0943081.X, (专利)

  (5) 黄春宇; 刁梁辉; 陈现; 李玉叶; 连若纯; 陈聪 ; 一种用于评估子宫内膜容受性的试剂盒及其使用方法, 2017-10-31, 中国, ZL 2016 1 0021908. X,, (专利)

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